Synthetic Peptide
TB-500
Thymosin Beta-4 Fragment
TB-500 is a lab-made copy of the most active part of a natural protein called Thymosin Beta-4. It is researched for its role in tissue repair, flexibility, and whole-body recovery. In studies it works by helping cells move to where they are needed and by supporting the growth of new blood vessels in healing models.
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Third-party tested. COA available for this batch (≥99.1% purity).
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Required to reconstitute peptides - not included.
Overview
TB-500 is a synthetic peptide associated in the research-chemical literature with the actin-binding region of thymosin beta-4 (T-beta-4), a naturally occurring 43-amino-acid peptide found in many mammalian cell types. The fragment marketed as TB-500 is frequently linked to the conserved LKKTET actin-binding motif that investigators have studied in connection with T-beta-4 in research models. VANTA supplies this TB-500 peptide strictly as a reference material for in-vitro and laboratory research, not as a supplement, drug, or medical product.
The most extensively characterized property of thymosin beta-4 in published work is its binding to monomeric globular actin (G-actin), where it is reported to form a roughly 1:1 complex and is associated with cytoskeletal dynamics in research models. Review and primary literature have also examined the conserved actin-binding site in relation to angiogenic readouts and cell migration in preclinical and in-vitro systems. These descriptions summarize findings reported by researchers and are presented only as a record of the published literature, not as conclusions about effect.
Researchers evaluating where to buy TB-500 for research typically weigh analytical identity and purity above all, because sequence errors, truncation products, and residual reagents can quietly confound an experiment. Every research grade TB-500 lot from VANTA is confirmed by mass spectrometry against the expected theoretical mass and assessed by reverse-phase HPLC, which resolves the main peak from related impurities. Each batch ships with a per-lot Certificate of Analysis tying the material to its own analytical record.
Research Areas
Handling & Reconstitution
TB-500 ships as a lyophilized powder and is handled only in a controlled laboratory setting. The lyophilized peptide is stored at -20 degrees C; once reconstituted with an appropriate solvent for in-vitro work, it is kept refrigerated at 2-8 degrees C. Researchers should minimize freeze-thaw cycles, protect vials from light and moisture, and follow institutional protocols for reconstitution, aliquoting, and storage to preserve sample integrity.
Frequently asked questions
What is TB-500?
TB-500 is a synthetic peptide used in the research-chemical literature for the actin-binding region of thymosin beta-4 (T-beta-4), a naturally occurring 43-amino-acid peptide. It is associated with the conserved LKKTET actin-binding motif and is supplied by VANTA strictly as a reference material for laboratory research.
What form and purity is the TB-500 peptide supplied in?
This TB-500 peptide is supplied as a lyophilized powder. Identity is confirmed by mass spectrometry against the expected theoretical mass, and purity is assessed by reverse-phase HPLC, which separates the main peak from truncation and deletion products to report a percentage purity figure for each lot.
How should TB-500 be stored and reconstituted for research?
Store the lyophilized TB-500 at -20 degrees C. After reconstitution with a suitable solvent for in-vitro work, keep it refrigerated at 2-8 degrees C. Minimize freeze-thaw cycles and protect vials from light and moisture, following your institutional handling protocols at all times.
Does VANTA provide third-party testing and a COA for TB-500?
Yes. VANTA treats every TB-500 lot as something to be measured, not assumed. Each batch ships with a per-batch Certificate of Analysis documenting the reverse-phase HPLC purity result and the mass spectrometry identity confirmation for that specific lot, supporting traceable and reproducible research.
What research areas is TB-500 studied in?
In published preclinical and in-vitro literature, TB-500 and thymosin beta-4 appear across research areas including actin sequestration and cytoskeletal dynamics, angiogenesis, cell migration, dermal and cutaneous wound models, and cardiac and coronary vessel development. These references describe laboratory and animal-model observations, not therapeutic outcomes.
Is TB-500 intended for human use?
No. TB-500 is sold strictly for laboratory and in-vitro research use by qualified professionals. It is not for human or veterinary use, ingestion, injection, or any form of consumption, and is not a drug, food, cosmetic, or medical device. Nothing here is medical advice or a claim of effect.
Specifications
- Research Class
- Synthetic Peptide
- Molecular Formula
- C212H350N56O78S
- Molar Mass
- 4963.49 g/mol
- Half-Life
- ~2-3 hours
- Form
- Lyophilized Powder
- Storage
- Lyophilized: -20°C. Reconstituted: 2-8°C.
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use. Must be 21+ to purchase.
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