Synthetic Heptapeptide
Semax
Neurogenic Heptapeptide
Semax is a lab-made peptide based on a fragment of the natural hormone ACTH. It is researched for focus, mental clarity, and protecting nerve cells. In studies it is examined for raising BDNF and NGF, two proteins that support brain-cell growth, and for steadying the brain's response to stress.
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Third-party tested. COA available for this batch (≥99.2% purity).
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Add bacteriostatic water to your order
Required to reconstitute peptides - not included.
Overview
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) structurally based on the ACTH(4-7) fragment extended with a C-terminal Pro-Gly-Pro tripeptide. In the literature it is described as a peptide related to the adrenocorticotropic hormone fragment region that lacks the classic corticotropic activity of the parent molecule. The Pro-Gly-Pro motif is generally characterized as a stabilizing addition associated with greater resistance to enzymatic degradation in experimental preparations. VANTA supplies this Semax peptide strictly as a reference compound for in-vitro and laboratory research use only.
A recurring theme in the Semax literature is its association with the neurotrophin system. Preclinical work by Dolotov and colleagues reported the heptapeptide was linked to brain-derived neurotrophic factor (BDNF) expression across several regions of the rat brain in vivo, and a 2006 Brain Research study described Semax modulating BDNF protein and trkB receptor activation in the rat hippocampus. Other mechanistic investigations have examined the peptide in relation to nerve growth factor (NGF), intracellular signaling pathway genes, and melanocortin-receptor pharmacology in animal and cell-based research models.
Researchers reference this ACTH-fragment peptide when designing experiments around BDNF/trkB signaling, neurotrophin gene expression, and melanocortin pathways. Research grade Semax has been studied across preclinical paradigms including rodent models of cerebral ischemia and ischemia-reperfusion, MPTP-induced lesions of the dopaminergic system, and basal forebrain cholinergic neuron survival in vitro. These are published observations in laboratory and animal systems, not statements about outcomes in humans. Semax for research from VANTA supports controlled, reference-grade experimentation only.
Handling & Reconstitution
Semax ships as a lyophilized powder and should be stored at -20C in its sealed vial, protected from light and moisture, until a study begins. For research preparation, the lyophilized peptide is typically reconstituted in a suitable sterile solvent such as bacteriostatic water and gently swirled rather than shaken to preserve the heptapeptide structure. Reconstituted solutions are kept refrigerated and handled per each laboratory's established protocols. For laboratory research use only.
Frequently asked questions
What is Semax?
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro, structurally based on the ACTH(4-7) fragment extended with a Pro-Gly-Pro tripeptide. The published literature categorizes it as a melanocortin-derived (ACTH-fragment) regulatory peptide studied in preclinical neuroscience research models.
What form and purity is this Semax peptide?
VANTA supplies Semax as a lyophilized powder intended as reference-grade research material. Purity is assessed by reversed-phase HPLC, and identity is confirmed by mass spectrometry to verify the expected molecular mass of the Met-Glu-His-Phe-Pro-Gly-Pro sequence before each lot is released.
How should Semax be stored and reconstituted for research?
Store the lyophilized Semax at -20C in its sealed vial, away from light and moisture. For research preparation it is typically reconstituted in a sterile solvent such as bacteriostatic water, swirled gently, then kept refrigerated and used according to each laboratory's own handling protocols.
Is Semax third-party tested and does it ship with a COA?
Yes. Each Semax lot is documented for identity and purity by HPLC and mass spectrometry, and every batch ships with a per-batch Certificate of Analysis recording the analytical results for that specific lot, so researchers can maintain chain-of-evidence for the material used in their work.
What research areas is Semax studied in?
Published literature references Semax in preclinical work on the neurotrophin system, including BDNF and NGF expression and trkB signaling, as well as rodent models of cerebral ischemia-reperfusion, dopaminergic-system lesions, and melanocortin-receptor pharmacology. These are findings in animal and in-vitro systems, not human outcomes.
Is Semax intended for human use?
No. Semax from VANTA is supplied strictly for laboratory and in-vitro research use only. It is not a drug, supplement, or medical product, and it is not intended for human or animal consumption, administration, diagnosis, or any therapeutic application of any kind.
Specifications
- Research Class
- Synthetic Heptapeptide
- Form
- Lyophilized Powder
- Storage
- Lyophilized: -20°C.
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use. Must be 21+ to purchase.
