Mitochondrial Peptide
MOTS-c
Mitochondrial-Derived Peptide
MOTS-c is a peptide produced inside the mitochondria, the energy centers of the cell. It is researched for how the body manages metabolism and insulin sensitivity. In studies it is described as an exercise mimetic, meaning it is examined for triggering some of the same cellular signals that physical activity does.
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Overview
MOTS-c is a mitochondrial-derived peptide of roughly 16 amino acids encoded within the mitochondrial 12S rRNA gene region. It belongs to a class the literature calls mitochondrial-derived peptides (MDPs), studied as putative signaling molecules between the mitochondria and the rest of the cell. In cell-based and animal models, MOTS-c has been detected in skeletal muscle and in circulation, and investigators have examined how its expression appears to shift under metabolic stress. VANTA supplies the MOTS-c peptide strictly as a reference compound for in-vitro and preclinical laboratory investigation.
In published preclinical and in-vitro work, MOTS-c has been most frequently associated with the AMP-activated protein kinase (AMPK) signaling axis. Researchers report it appears to influence the folate-methionine cycle and AICAR/AMPK signaling in cell models, and that under glucose restriction it can translocate to the nucleus alongside altered stress-response and antioxidant-response-element gene expression. Additional studies examine MOTS-c in PGC-1alpha-related and AMPK-dependent mitochondrial bioenergetics in muscle models. These describe mechanisms reported in laboratory systems, not effects in humans.
MOTS-c has also been investigated as a candidate exercise-associated factor, which is why it is sometimes described as an exercise mimetic in the research literature. In aging-model studies, MOTS-c has been examined in mice alongside measures such as treadmill running time, and exercise-induced changes in endogenous MOTS-c have been observed in muscle and circulation. Research grade MOTS-c from VANTA ships lyophilized for laboratory metabolic, skeletal-muscle, and aging-model studies, with characterization documented per lot.
Research Areas
Handling & Reconstitution
MOTS-c ships as a lyophilized powder and should be stored at -20°C in its sealed vial, protected from light and moisture, until a study begins. For reconstitution in a laboratory setting, researchers typically introduce a suitable sterile diluent slowly down the vial wall and swirl gently rather than shaking, to preserve peptide integrity. Reconstituted aliquots are generally kept cold and used within the timeframe defined by the experimental protocol.
Frequently asked questions
What is MOTS-c?
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a short peptide of about 16 amino acids encoded within the mitochondrial 12S rRNA gene region. It is one of the mitochondrial-derived peptides studied in preclinical metabolic, skeletal-muscle, and aging models as a putative cellular signaling molecule.
What research areas is the MOTS-c peptide studied in?
In the literature, MOTS-c is examined in models of metabolic homeostasis, insulin sensitivity, and skeletal-muscle bioenergetics, and as a candidate exercise-associated factor. Reported mechanisms center on AMPK signaling and PGC-1alpha-related pathways. These are observations from controlled preclinical models, not outcomes established in humans.
What form and purity does VANTA's MOTS-c come in?
VANTA supplies MOTS-c as a lyophilized powder. Purity is assessed by reversed-phase HPLC, which resolves the target peptide from related impurities to support a quantified purity value, and identity is confirmed by mass spectrometry against the defined MOTS-c sequence.
How should MOTS-c be stored and reconstituted?
Store the lyophilized MOTS-c powder at -20°C, sealed and away from light and moisture. For laboratory reconstitution, add a suitable sterile diluent slowly down the vial wall and swirl gently rather than shaking. Keep reconstituted material cold and use it within the protocol's defined window.
Does VANTA provide a COA and third-party testing for MOTS-c?
Yes. Every MOTS-c lot is characterized before release and ships with a per-batch Certificate of Analysis documenting HPLC purity and mass-spectrometry identity alongside lot identifiers. This supports traceability and experimental reproducibility, letting a researcher match the material in hand to its analytical record.
Is MOTS-c intended for human use?
No. MOTS-c is sold strictly for laboratory and research use only. It is not for human or veterinary use, consumption, or administration, and nothing on this page constitutes medical, therapeutic, or dosing guidance.
Specifications
- Research Class
- Mitochondrial Peptide
- Half-Life
- ~3-4 hours
- Form
- Lyophilized Powder
- Storage
- Lyophilized: -20°C.
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use. Must be 21+ to purchase.
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