Growth Hormone Releasing Peptide
Ipamorelin
Selective GHRP
Ipamorelin is a peptide studied for signaling the body to release its own growth hormone in short, natural pulses. It works by gently nudging the gland that makes growth hormone, and in research it is valued for being selective, meaning it has been studied for triggering that release without meaningfully stirring up stress hormones, prolactin, or hunger. This selective profile is why researchers often use it as a reference compound when studying the growth hormone system.
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Third-party tested. COA available for this batch (≥99.3% purity).
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Add bacteriostatic water to your order
Required to reconstitute peptides - not included.
Overview
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) first described in the late 1990s and characterized in the literature as a selective growth hormone secretagogue (GHS). Structurally derived from the growth hormone-releasing peptide (GHRP) family, this ipamorelin peptide was identified within a series of analogues lacking the central Ala-Trp dipeptide of GHRP-1. VANTA supplies research grade ipamorelin strictly as a reference compound for in-vitro and laboratory investigation, never for human or veterinary use.
In the published literature, ipamorelin is described as an agonist of the growth hormone secretagogue receptor (GHS-R1a), the same G-protein-coupled receptor recognized by the endogenous ligand ghrelin. Pharmacological profiling in preclinical systems indicated it acts via a GHRP-like pathway rather than the GHRH receptor. A recurring theme across rodent and in-vitro models is selectivity: investigators reported growth hormone release from primary pituitary cells with no significant change in ACTH or cortisol, distinguishing it from related secretagogues in those research settings.
Because of that reported selectivity profile, ipamorelin is frequently referenced as a tool compound when designing experiments that probe GHS-R signaling with a comparatively narrow endocrine footprint in animal and cell-based models. It has been examined alongside related peptides in comparative research contexts, such as ipamorelin cjc-1295 study designs and ipamorelin vs sermorelin literature. These are literature-derived observations to inform experimental design only, not assertions of effect outside the cited research settings.
Handling & Reconstitution
Ipamorelin ships as a lyophilized powder. Researchers typically reconstitute the vial with bacteriostatic or sterile water for laboratory preparation, swirling gently rather than shaking to preserve the pentapeptide. Store the sealed lyophilized powder at -20C to maintain stability. Once reconstituted, solutions are generally kept refrigerated and protected from light. Handle under standard laboratory practice; this material is for in-vitro research use only.
Frequently asked questions
What is ipamorelin?
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) characterized in the literature as a selective growth hormone secretagogue and GHS-R1a agonist. It was first described in the late 1990s and is studied strictly as a research chemical in preclinical and in-vitro models.
What form and purity does VANTA's ipamorelin ship in?
VANTA supplies ipamorelin as a lyophilized powder. Every lot is screened by reversed-phase HPLC for chromatographic purity and confirmed by mass spectrometry against the expected pentapeptide mass, giving researchers reference-grade material for the lab.
How should research grade ipamorelin be stored and reconstituted?
Store the lyophilized powder sealed at -20C to preserve stability. Researchers typically reconstitute with bacteriostatic or sterile water, swirling gently to avoid degrading the peptide, then keep reconstituted solutions refrigerated and shielded from light during laboratory work.
Is ipamorelin third-party tested and does it come with a COA?
Yes. Each batch ships with a per-batch Certificate of Analysis documenting the HPLC purity figure and MS identity confirmation for that specific lot, so researchers can match the material in hand to its analytical record for reproducibility and traceability.
What research areas is ipamorelin studied in?
In the preclinical literature, ipamorelin has been examined in models of growth hormone release from pituitary cells, somatotroph response, gastrointestinal transit, glucocorticoid-associated bone changes, and pancreatic insulin release. These are observations within research models, not indications of any outcome in humans.
Is ipamorelin intended for human use?
No. Ipamorelin is supplied strictly for laboratory research use only. It is not a drug, supplement, or article intended for human or animal consumption, diagnosis, or treatment, and must be handled only by qualified researchers in a controlled setting.
Specifications
- Research Class
- Growth Hormone Releasing Peptide
- Molecular Formula
- C38H49N9O5
- Molar Mass
- 711.85 g/mol
- Half-Life
- ~2 hours
- Form
- Lyophilized Powder
- Storage
- Lyophilized: -20°C.
For laboratory research use only. Not for human consumption, diagnostic, or therapeutic use. Must be 21+ to purchase.
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